Abstract：With the deepening of economic globalization and large scale industrial change, corporate social responsibility (CSR) has got more and more attention, and the enterprises impact on the sustainable development of the whole world has become the focus of the international community. Foreign-invested enterprises began to settle down in China during the late 1970s, and then grew up in the background of China’s reform and opening up. Since then, they have played important roles in promoting China’s rapid economic development, being active in China’s social and economic arena as a vital force. However, with the continuous development of foreign-invested enterprises in China, the phenomenon of some of them failing to perform the social responsibility constantly appears, and becomes increasingly fierce, which has caused widespread concern in the community. Therefore, the study of CSR of foreign-invested enterprises in China has a very pressing theoretical and practical significance. This chapter based on such a background, finds out the factors that influence the CSR of foreign-invested enterprises in China through the analysis of their social responsibility status, has an in-depth research on the problem of their CSR relying on related theories of enterprise social responsibility, stakeholders, supply chain, etc., through four angles—economic responsibility, regulations responsibility, ethics responsibility and ecological responsibility, and on this basis puts forward the strategic countermeasures of strengthening the construction of CSR.